The Rapid Plasma Reagin (RPR) Test is a non-treponemal flocculation test. It detects the reagent, an antibody found in people with syphilis or other treponemal diseases. Treponema pallidum, the etiological agent responsible for syphilis, produces at least two types of antibodies in human infections. These two types are treponemal antibodies and reactin antibodies. Reagin antibody is detected by tests such as the RPR Antigen Card Test we offer. If antibody reagent is present in the sample, it will cause black clumps to form against the white background of the test card. Non-reactive samples will give an even, light gray homogeneous suspension.
Syphilis is a sexually transmitted disease caused by the bacterium Treponema Pallidum. Serologically, tests are performed to detect antibodies in the blood. VDRL/RPR tests that become positive 4-8 weeks after primary syphilis are the most commonly used tests for screening and diagnosis. However, false positives and negatives may occur in these tests. Treponema pallidum gel agglunitation is defined as the detection of anti-Treponema antibodies present in serum samples. These antibodies react with chimeric antigenic proteins of treponema, which are attached to sheep erythrocytes for agglutination. Results against four different epitopes are seen in one microtube. It can be used easily and safely in almost all laboratories, including primary care laboratories. Thanks to its ease of standardization, it contributes to the reduction of application errors and is suitable for automation.
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